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TCR engineered T cells for solid tumor immunotherapy.

ABSTRACT: T cell immunotherapy remains an attractive approach for cancer immunotherapy. T cell immunotherapy mainly employs chimeric antigen receptor (CAR)- and T cell receptor (TCR)-engineered T cells. CAR-T cell therapy has been an essential breakthrough in treating hematological malignancies. TCR-T cells can recognize antigens expressed both on cell surfaces and in intracellular compartments. Although TCR-T cells have not been approved for clinical application, a number of clinical trials have been performed, particularly for solid tumors. In this article, we summarized current TCR-T cell advances and their potential advantages for solid tumor immunotherapy.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC9210724 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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TCR engineered T cells for solid tumor immunotherapy.

Zhang Yikai Y Liu Zhipeng Z Wei Wei W Li Yangqiu Y

Experimental hematology & oncology 20220620 1

T cell immunotherapy remains an attractive approach for cancer immunotherapy. T cell immunotherapy mainly employs chimeric antigen receptor (CAR)- and T cell receptor (TCR)-engineered T cells. CAR-T cell therapy has been an essential breakthrough in treating hematological malignancies. TCR-T cells can recognize antigens expressed both on cell surfaces and in intracellular compartments. Although TCR-T cells have not been approved for clinical application, a number of clinical trials have been per ...[more]

PMID: 35725570

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