High serum uric acid trajectories are associated with risk of myocardial infarction and all-cause mortality in general Chinese population.

ABSTRACT:

Background

Long-term patterns of serum uric acid (SUA) and their association with the risk of myocardial infarction (MI) and mortality are poorly characterized as prior studies measured SUA at a single time point. This study aimed to identify SUA trajectories and determine their associations with incident MI and all-cause mortality.

Methods

We included 85,503 participants who were free of MI in or prior 2012 from the Kailuan study. SUA trajectories during 2006-2012 were identified by group-based trajectory modeling. Cox proportional hazard models were used to assess the association of SUA trajectories with MI and all-cause mortality.

Results

We identified three SUA trajectories during 2006-2012: low-stable (n=44,124, mean SUA: 236-249 μmol/L), moderate-stable (n=34,43

SUBMITTER: Tian X 

PROVIDER: S-EPMC9210742 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature