Estrogen replacement therapy: effects of starting age on final height of girls with chronic kidney disease and short stature.

ABSTRACT:

Introduction

We investigated the age of starting Estrogen replacement therapy as a key parameter for reaching near normal Final Height (FH) in Chronic Kidney Disease (CKD) girls with growth retardation.

Method

This open label, quasi-experimental designed and matched controlled clinical trial was performed on CKD girls with short stature and later onset of puberty or delayed puberty according to clinical and laboratory investigations. Participants of group 1 and 2 had been treated with Growth Hormone (GH), and Ethinyl Estradiol (EE). EE was administered from 11 and 13 yrs. old in groups 1 and 2 respectively. Group 3 was selected from patients that did not accept to start GH or EE till 15 years old. The effect of the age of starting EE on FH, GH therapy outcomes, bone density,

SUBMITTER: Amirkashani D 

PROVIDER: S-EPMC9210764 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature