Mitochondrial DNA sequences and transcriptomic profiles for elucidating the genetic underpinnings of cisplatin responsiveness in oral squamous cell carcinoma.

ABSTRACT:

Objectives

Functional genetic variation plays an important role in predicting patients' response to chemotherapeutic agents. A growing catalogue of mitochondrial DNA (mtDNA) alterations in various cancers point to their important roles in altering the drug responsiveness and survival of cancer cells. In this work, we report the mtDNA sequences, obtained using a nanopore sequencer that can directly sequence unamplified DNA, and the transcriptomes of oral squamous cell carcinoma (OSCC) cell lines with differing responses to cisplatin, to explore the interplay between mtDNA alterations, epigenetic regulation of gene expression, and cisplatin response in OSCC.

Data description

Two human OSCC cell lines, namely H103 and SAS, and drug-resistant stem-like cells derived from SAS wer

SUBMITTER: Aminuddin A 

PROVIDER: S-EPMC9210765 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature