FG-4592 protects the intestine from irradiation-induced injury by targeting the TLR4 signaling pathway.

ABSTRACT:

Background

Severe ionizing radiation (IR)-induced intestinal injury associates with high mortality, which is a worldwide problem requiring urgent attention. In recent years, studies have found that the PHD-HIF signaling pathway may play key roles in IR-induced intestinal injury, and we found that FG-4592, the PHD inhibitor, has significant radioprotective effects on IR-induced intestinal injury.

Methods

In the presence or absence of FG-4592 treatment, the survival time, pathology, cell viability, cell apoptosis, and organoids of mice after irradiation were compared, and the mechanism was verified after transcriptome sequencing. The data were analyzed using SPSS ver. 19 software.

Results

Our results show that FG-4592 had significant radioprotective effects on the intes

SUBMITTER: Feng Z 

PROVIDER: S-EPMC9210818 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature