Circulating miR-627-5p and miR-199a-5p are promising diagnostic biomarkers of colorectal neoplasia.

ABSTRACT:

Background

Early detection of colorectal neoplasms, including colorectal cancers (CRCs) and advanced colorectal adenomas (AAs), is crucial to improve patient survival. Circulating microRNAs (miRNAs) in peripheral blood are emerging as noninvasive diagnostic markers for multiple cancers, but their potential for screening colorectal neoplasms remains ambiguous.

Aim

To identify candidate circulating cell-free miRNAs as diagnostic biomarkers in patients with colorectal neoplasms.

Methods

The study was divided into three phases: (1) Candidate miRNAs were selected from three public miRNA datasets using differential gene expression analysis methods; (2) an independent set of serum samples from 60 CRC patients, 60 AA patients and 30 healthy controls (HCs) was included and ana

SUBMITTER: Zhao DY 

PROVIDER: S-EPMC9210874 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature