Light Regulates Acinetobacter baumannii Chromosomal and pAB3 Plasmid Genes at 37°C.

ABSTRACT: The opportunistic pathogen A. baumannii has a remarkable capacity to persist in the hospital environment and cause devastating human infections. This capacity can be attributed partly to the sensing and regulatory systems that enable this pathogen to modify its physiology based on environmental cues. One of the signals that A. baumannii senses and responds to is light through the sensing and regulatory roles of the BlsA photoreceptor protein in cells cultured at temperatures below 30°C. This report presents evidence that a light stimulon is operational at 37°C, a condition at which the BlsA production and activity are drastically impaired. Global transcriptional analysis showed that the 37°C light stimulon includes the differential expression of chromosomal genes encoding a wide range of f

SUBMITTER: Squire MS 

PROVIDER: S-EPMC9210970 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature