Management of early melanoma recurrence despite adjuvant anti-PD-1 antibody therapy^☆.

ABSTRACT:

Background

Anti-programmed cell death protein 1 (PD-1) antibodies (PD1) prolong recurrence-free survival in high-risk resected melanoma; however, approximately 25%-30% of patients recur within 1 year. This study describes the pattern of recurrence, management and outcomes of patients who recur with adjuvant PD1 therapy.

Patients and methods

Consecutive patients from 16 centres who recurred having received adjuvant PD1 therapy for resected stage III/IV melanoma were studied. Recurrence characteristics, management and outcomes were examined; patients with mucosal melanoma were analysed separately.

Results

Melanoma recurrence occurred in 147 (17%) of ∼850 patients treated with adjuvant PD1. In those with cutaneous melanoma (n = 136), median time to recurrence was 4.6 mon

SUBMITTER: Owen CN 

PROVIDER: S-EPMC9211001 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature