Functional Neuroimaging Correlates of Placebo Response in Patients With Depressive or Anxiety Disorders: A Systematic Review.

ABSTRACT:

Background

The mechanisms underlying placebo effects of psychotropic drugs remain poorly understood. We carried out the first, to our knowledge, systematic review of functional neuroimaging correlates of placebo response in adults with anxiety/depressive disorders.

Methods

We systematically searched a large set of databases up to February 2021 based on a pre-registered protocol (PROSPERO CRD42019156911). We extracted neuroimaging data related to clinical improvement following placebo or related to placebo mechanisms. We did not perform a meta-analysis due to the small number of included studies and significant heterogeneity in study design and outcome measures.

Results

We found 12 relevant studies for depressive disorders and 4 for anxiety disorders. Activity in the v

SUBMITTER: Huneke NTM 

PROVIDER: S-EPMC9211006 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature