A proposed theoretical framework for retinal biomarkers.

ABSTRACT:

Objective

Propose a theoretical framework for retinal biomarkers of Alzheimer's disease (AD).

Background

The retina and brain share important biological features that are relevant to AD. Developing retinal biomarkers of AD is a strategic priority but as yet none have been validated for clinical use. Part of the reason may be that fundamental inferential assumptions have been overlooked. Failing to recognize these assumptions will disadvantage biomarker discovery and validation, but incorporating them into analyses could facilitate translation.

New theory

The biological assumption that a disease causes analogous effects in the brain and retina can be expressed within a Bayesian network. This allows inferences about abstract theory and individual events, and provides an

SUBMITTER: MacCormick IJC 

PROVIDER: S-EPMC9211063 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature