Depression, religiosity, and telomere length in the Study on Stress, Spirituality, and Health (SSSH).

ABSTRACT: Prospective studies on the association between depression and telomere length have produced mixed results and have been largely limited to European ancestry populations. We examined the associations between depression and telomere length, and the modifying influence of religion and spirituality, in four cohorts, each representing a different race/ethnic population. Relative leukocyte telomere length (RTL) was measured by a quantitative polymerase chain reaction. Our result showed that depression was not associated with RTL (percent difference: 3.0 95% CI: -3.9, 10.5; p = 0.41; p-heterogeneity across studies = 0.67) overall or in cohort-specific analyses. However, in cohort-specific analyses, there was some evidence of effect modification by the extent of religiosity or spirituality, religi

SUBMITTER: Isehunwa OO 

PROVIDER: S-EPMC9211376 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature