Comparative Transcriptomics Reveal Possible Mechanisms of Amphotericin B Resistance in Candida auris.

ABSTRACT: Candida auris is an emerging multidrug-resistant human fungal pathogen often refractory to treatment by all classes of antifungal drugs. Amphotericin B (AmB) is a fungicidal drug that, despite its toxic side effects, remains a drug of choice for the treatment of drug-resistant fungal infections, including those caused by C. auris. However, the molecular mechanisms underlying AmB resistance are poorly understood. In this study, we present data that suggests membrane lipid alterations and chromatin modifications are critical processes that may contribute to or cause adaptive AmB resistance in clinical C. auris isolates. To determine the plausible cause of increased AmB resistance, we performed RNA-seq of AmB-resistant and sensitive C. auris isolates. Remarkably, AmB-resistant strains show a

SUBMITTER: Shivarathri R 

PROVIDER: S-EPMC9211394 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature