Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy.

ABSTRACT:

Background and hypothesis

Hallucinations may be driven by an excessive influence of prior expectations on current experience. Initial work has supported that contention and implicated the anterior insula in the weighting of prior beliefs.

Study design

Here we induce hallucinated tones by associating tones with the presentation of a visual cue. We find that people with schizophrenia who hear voices are more prone to the effect and using computational modeling we show they overweight their prior beliefs. In the same participants, we also measured glutamate levels in anterior insula, anterior cingulate, dorsolateral prefrontal, and auditory cortices, using magnetic resonance spectroscopy.

Study results

We found a negative relationship between prior-overweighting and glut

SUBMITTER: Leptourgos P 

PROVIDER: S-EPMC9212089 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature