Probiotics Plus Dietary Fiber Supplements Attenuate Olanzapine-Induced Weight Gain in Drug-Naive First-Episode Schizophrenia Patients: Two Randomized Clinical Trials.

ABSTRACT:

Background and hypothesis

Antipsychotic-induced weight gain is associated with alterations to the composition of the gut microbiota. The purpose of this study was to determine the effect of probiotics plus dietary fiber on antipsychotic-induced weight gain.

Study design

Two sequential, randomized clinical trials were conducted. In Study 1, 90 drug-naïve, first-episode schizophrenia patients were randomized to receive either olanzapine plus probiotics or olanzapine monotherapy for 12 weeks. In Study 2, 60 drug-naïve, first-episode schizophrenia patients were randomly assigned to receive either olanzapine plus probiotics and dietary fiber or olanzapine monotherapy for 12 weeks.

Study results

In Study 1, no significant differences in weight gain were observed between the

SUBMITTER: Huang J 

PROVIDER: S-EPMC9212091 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature