Serum levels of soluble HLA-G correlate with disease activity in pediatric patients with Crohn's disease.

ABSTRACT:

Background

Human leukocyte antigen (HLA)-G, a member of the HLA family, is crucial for fetomaternal tolerance. Transmembrane or circulating/soluble HLA-G (sHLA-G) is elevated in autoimmune conditions and the tumor microenvironment. Circulating sHLA-G levels and their association with disease activity have not yet been assessed in pediatric patients with inflammatory bowel disease (IBD). This study aimed to quantify the serum sHLA-G levels of pediatric patients with IBD and assess the association of serum sHLA-G with disease activity.

Methods

: We enrolled 24 pediatric IBD patients Crohn's disease (CD) and ulcerative colitis (UC), n = 12 each] and 24 healthy controls. Based on the disease activity index, five and seven of the CD patients had mild and moderate/severe disease,

SUBMITTER: Cansever M 

PROVIDER: S-EPMC9212116 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature