Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium.

ABSTRACT: SARS-CoV-2 contains four structural proteins in its genome. These proteins aid in the assembly and budding of new virions at the ER-Golgi intermediate compartment (ERGIC). Current fundamental research efforts largely focus on one of these proteins - the spike (S) protein. Since successful antiviral therapies are likely to target multiple viral components, there is considerable interest in understanding the biophysical role of its other structural proteins, in particular structural membrane proteins. Here, we have focused our efforts on the characterization of the full-length envelope (E) protein from SARS-CoV-2, combining experimental and computational approaches. Recombinant expression of the full-length E protein from SARS-CoV-2 reveals that this membrane protein is capable of independen

SUBMITTER: Mehregan A 

PROVIDER: S-EPMC9212275 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature