Preexisting comorbidities shape the immune response associated with severe COVID-19.

ABSTRACT:

Background

Comorbidities are risk factors for development of severe coronavirus disease 2019 (COVID-19). However, the extent to which an underlying comorbidity influences the immune response to severe acute respiratory syndrome coronavirus 2 remains unknown.

Objective

Our aim was to investigate the complex interrelations of comorbidities, the immune response, and patient outcome in COVID-19.

Methods

We used high-throughput, high-dimensional, single-cell mapping of peripheral blood leukocytes and algorithm-guided analysis.

Results

We discovered characteristic immune signatures associated not only with severe COVID-19 but also with the underlying medical condition. Different factors of the metabolic syndrome (obesity, hypertension, and diabetes) affected distinct

SUBMITTER: Kreutmair S 

PROVIDER: S-EPMC9212690 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature