Efficacy and hazards of 425 nm oral cavity light dosing to inactivate SARS-CoV-2.

ABSTRACT:

Objective

Using a battery of preclinical tests to support development of a light-based treatment for COVID-19, establish a range of 425 nm light doses that are non-hazardous to the tissues of the oral cavity and assess whether a 425 nm light dose in this non-hazardous range can inactivate SARS-CoV-2 in artificial saliva.

Methods

The potential hazards to oral tissues associated with a range of acute 425 nm light doses were assessed using a battery of four preclinical tests: (1) cytotoxicity, using well-differentiated human large airway and buccal epithelial models; (2) toxicity to commensal oral bacteria, using a panel of model organisms; (3) light-induced histopathological changes, using ex vivo porcine esophageal tissue, and (4) thermal damage, by dosing the oropharynx of i

SUBMITTER: Stockslager MA 

PROVIDER: S-EPMC9212724 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature