Investigating whole-brain metabolite abnormalities in the chronic stages of moderate or severe traumatic brain injury.

ABSTRACT:

Background

Evidence suggests that neurometabolic abnormalities can persist after traumatic brain injury (TBI) and drive clinical symptoms such as fatigue and cognitive disruption. Magnetic resonance spectroscopy has been used to investigate metabolite abnormalities following TBI, but few studies have obtained data beyond the subacute stage or over large brain regions.

Objective

To measure whole-brain metabolites in chronic stages of TBI.

Design

Observational study.

Setting

University.

Participants

Eleven men with a moderate or severe TBI more than 12 months prior and 10 age-matched healthy controls completed whole-brain spectroscopic imaging.

Main measures

Ratios of N-acetylaspartate (NAA), choline (CHO), and myo-inositol (MI) to creatine (CR) wer

SUBMITTER: Lin JC 

PROVIDER: S-EPMC9212770 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature