In-silico screening to delineate novel antagonists to SARS-CoV-2 nucleocapsid protein.

ABSTRACT: Since its inception, SARS-CoV-2 has crossed all borders and continues rampaging around the globe, causing profound economic damage and heavy burden on the scientific community and the healthcare fraternity and facilities. With the emergence of new variants, the global pandemic has prolonged and raised concerns regarding the existing therapies. Most of the identified mutants have the potential to exacerbate the already existing crisis. In line with the urgent need for promising antivirals against the novel coronavirus, we conducted an in-silico drug docking study using SeeSAR and other bioinformatics tools and identified prospective molecules that target the nucleocapsid protein of SARS-CoV-2. The highly conserved N protein plays a crucial role in viral assembly and pathogenicity by interac

SUBMITTER: Shahanshah MFH 

PROVIDER: S-EPMC9212792 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature