Characterization of Phrenic Nerve Response to Pulsed Field Ablation.

ABSTRACT:

Background

Phrenic nerve palsy is a well-known complication of cardiac ablation, resulting from the application of direct thermal energy. Emerging pulsed field ablation (PFA) may reduce the risk of phrenic nerve injury but has not been well characterized.

Methods

Accelerometers and continuous pacing were used during PFA deliveries in a porcine model. Acute dose response was established in a first experimental phase with ascending PFA intensity delivered to the phrenic nerve (n=12). In a second phase, nerves were targeted with a single ablation level to observe the effect of repetitive ablations on nerve function (n=4). A third chronic phase characterized assessed histopathology of nerves adjacent to ablated cardiac tissue (n=6).

Results

Acutely, we observed a dose-dep

SUBMITTER: Howard B 

PROVIDER: S-EPMC9213085 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature