Biocatalytic oxidative cross-coupling reactions for biaryl bond formation.

ABSTRACT: Biaryl compounds, with two connected aromatic rings, are found across medicine, materials science and asymmetric catalysis^1,2. The necessity of joining arene building blocks to access these valuable compounds has inspired several approaches for biaryl bond formation and challenged chemists to develop increasingly concise and robust methods for this task³. Oxidative coupling of two C-H bonds offers an efficient strategy for the formation of a biaryl C-C bond; however, fundamental challenges remain in controlling the reactivity and selectivity for uniting a given pair of substrates^4,5. Biocatalytic oxidative cross-coupling reactions have the potential to overcome limitations inherent to numerous small-molecule-mediated methods by providing a paradigm with cat

SUBMITTER: Zetzsche LE 

PROVIDER: S-EPMC9213091 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature