Data on the clinical, analytical, and laboratory factors associated with negative anion gaps at an academic medical center.

ABSTRACT: The anion gap is a calculated parameter derived from the difference between the major plasma cations and anions in serum/plasma or whole blood, with a widely used simple equation utilizing concentrations of sodium, chloride, and bicarbonate. While there is extensive literature on the clinical significance and causes of elevated anion gaps, there is comparatively less data on low anion gaps. Occasionally, anion gap calculations result in a negative number (-1 or less). From the published literature, causes of these 'negative anion gaps' include laboratory error, specimen contamination or interference, hypoalbuminemia, extreme hyperkalemia, bromism, and paraproteins from multiple myeloma or similar pathologic processes. The data in this article present results from retrospective review of cl

SUBMITTER: Laakman JM 

PROVIDER: S-EPMC9213217 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature