Clinical translation of a patient-specific scaffold-guided bone regeneration concept in four cases with large long bone defects.

ABSTRACT:

Background

Bone defects after trauma, infection, or tumour resection present a challenge for patients and clinicians. To date, autologous bone graft (ABG) is the gold standard for bone regeneration. To address the limitations of ABG such as limited harvest volume as well as overly fast remodelling and resorption, a new treatment strategy of scaffold-guided bone regeneration (SGBR) was developed. In a well-characterized sheep model of large to extra-large tibial segmental defects, three-dimensional (3D) printed composite scaffolds have shown clinically relevant biocompatibility and osteoconductive capacity in SGBR strategies. Here, we report four challenging clinical cases with large complex posttraumatic long bone defects using patient-specific SGBR as a successful treatment.

Me

SUBMITTER: Laubach M 

PROVIDER: S-EPMC9213234 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature