The altered multiscale dynamics of spontaneous brain activity in depression with Parkinson's disease.

ABSTRACT:

Background

Depression is one typical mood disorder in Parkinson's disease (DPD). The alterations in the resting-state brain activities are believed to be associated with DPD. These resting-state activities are regulated by neurophysiological components over multiple temporal scales. The multiscale dynamics of these spontaneous fluctuations are thus complex, but not well-characterized.

Objective

To characterize the complexity of the spontaneous blood-oxygen-level-dependent (BOLD) of fMRI in DPD. We hypothesized that (1) compared to non-depression PD (NDPD), the complexity in DPD would be lower; and (2) the diminished complexity would be associated with lower connections/communications between brain regions.

Methods

Twenty-nine participants (10 in DPD and 19 in NDPD) wh

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9213374 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature