Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae.

ABSTRACT: Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive behavior is the type VI secretion system (T6SS). Interestingly and in contrast to non-pandemic or environmental isolates, the T6SS of the O1 El Tor clade of V. cholerae, which is responsible for the ongoing 7th cholera pandemic, is largely silent under standard laboratory culture conditions. Instead, these strains induce their full T6SS capacity only under specific conditions such as growth on chitinous surfaces (signaled through TfoX and QstR) or when the cells encounter low intracellular c-di-GMP levels (TfoY-driven). In this study, we identifie

SUBMITTER: Drebes Dorr NC 

PROVIDER: S-EPMC9213491 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature