Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography.

ABSTRACT: Determining the optimal treatment course for a dermatologic burn wound requires knowledge of the wound's severity, as quantified by the depth of thermal damage. In current clinical practice, burn depth is inferred based exclusively on superficial visual assessment, a method which is subject to substantial error rates in the classification of partial thickness (second degree) burns. Here, we present methods for direct, quantitative determination of the depth extent of injury to the dermal collagen matrix using polarization-sensitive optical coherence tomography (PS-OCT). By visualizing the depth-dependence of the degree of polarization of light in the tissue, rather than cumulative retardation, we enable direct and volumetric assessment of local collagen status. We further augment our PS-OC

SUBMITTER: Cannon TM 

PROVIDER: S-EPMC9213509 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature