Association of metabolic health phenotypes, obesity, and hepatocellular carcinoma risk.

ABSTRACT:

Background

The obesity and hepatocellular carcinoma (HCC) risk association may differ by individuals' metabolic health status.

Aim

To investigate the association between obesity categories and HCC risk among individuals with different metabolic health phenotypes.

Methods

A case-control study among 518 HCC cases and 1,036 frequency-matched controls was conducted. Body mass index (BMI) was assessed before diagnosis. Pre-diagnosis data on dyslipidemia, hypertension, and diabetes were used to categorize participants as metabolically healthy or metabolically unhealthy. Participants were further categorized into metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW)

SUBMITTER: Nasereldin DS 

PROVIDER: S-EPMC9213572 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature