Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range.

ABSTRACT: Many medications of different indications have a relevant anticholinergic activity. The anticholinergic burden of medication has been shown to have significant effects on the cognition and the risk for cognitive impairment and dementia particularly in older patients. So far, most of the studies used data from geriatric patients and the effect of the anticholinergic burden on brain structures is still unexplored. Our study aimed to analyze possible associations of hippocampus and cholinergic basal forebrain volumes as vulnerable brain structures for the development of dementia and the anticholinergic burden in a population-based cohort of non-demented participants spanning the adult age range from 21 to 80 years. We analyzed associations between medication-related anticholinergic burden and

SUBMITTER: Kilimann I 

PROVIDER: S-EPMC9213601 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature