A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease.

ABSTRACT: Recent reports have suggested that the reactivation of otherwise transcriptionally silent transposable elements (TEs) might induce brain degeneration, either by dysregulating the expression of genes and pathways implicated in cognitive decline and dementia or through the induction of immune-mediated neuroinflammation resulting in the elimination of neural and glial cells. In the work we present here, we test the hypothesis that differentially expressed TEs in blood could be used as biomarkers of cognitive decline and development of AD. To this aim, we used a sample of aging subjects (age > 70) that developed late-onset Alzheimer's disease (LOAD) over a relatively short period of time (12-48 months), for which blood was available before and after their phenoconversion, and a group of cognit

SUBMITTER: Macciardi F 

PROVIDER: S-EPMC9213607 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature