Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation.

ABSTRACT: Adipose tissue dysfunction is strongly linked to the development of chronic inflammation and cardiometabolic disorders in aging. While much attention has been given to the role of resident adipose tissue immune cells in the disruption of homeostasis in obesity, age-specific effects remain understudied. Here, we identified and characterized a population of γδ T cells, which show unique age-dependent accumulation in the visceral adipose tissue (VAT) of both mice and humans. Diet-induced obesity likewise increased γδ T cell numbers; however, the effect was greater in the aged where the increase was independent of fat mass. γδ T cells in VAT express a tissue-resident memory T cell phenotype (CD44^hiCD62L^lowCD69⁺) and are predominantly IL-17A-producing cells. Tra

SUBMITTER: Bruno MEC 

PROVIDER: S-EPMC9213615 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature