Tetraspanin CD82 restrains phagocyte migration but supports macrophage activation.

ABSTRACT: Phagocytes migrate into tissues to combat infection and maintain tissue homeostasis. As dysregulated phagocyte migration and function can lead to inflammation or susceptibility to infection, identifying molecules that control these processes is critical. Here, we show that the tetraspanin CD82 restrains the migration of neutrophils and macrophages into tissues. Cd82 ^-/- phagocytes exhibited excessive migration during in vivo models of peritoneal inflammation, superfusion of CXCL1, retinopathy of prematurity, and infection with the protozoan parasite L. mexicana. However, with the latter, while Cd82 ^-/- macrophages infiltrated infection sites at higher proportions, cutaneous L. mexicana lesions were larger and persisted,

SUBMITTER: McGowan ENS 

PROVIDER: S-EPMC9213772 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature