Lattice-patterned collagen fibers and their dynamics in axolotl skin regeneration.

ABSTRACT: The morphology of collagen-producing cells and the structure of produced collagen in the dermis have not been well-described. This lack of insights has been a serious obstacle in the evaluation of skin regeneration. We succeeded in visualizing collagen-producing cells and produced collagen using the axolotl skin, which is highly transparent. The visualized dermal collagen had a lattice-like structure. The collagen-producing fibroblasts consistently possessed the lattice-patterned filopodia along with the lattice-patterned collagen network. The dynamics of this lattice-like structure were also verified in the skin regeneration process of axolotls, and it was found that the correct lattice-like structure was not reorganized after simple skin wounding but was reorganized in the presence of ne

SUBMITTER: Kashimoto R 

PROVIDER: S-EPMC9213773 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature