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Maternal and Neonatal SARS-CoV-2 Omicron Variant Neutralization after Antenatal mRNA Vaccination.

ABSTRACT: We evaluated the neutralization efficiency against SARS-CoV-2 omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against omicron were lacking at the time of delivery after two-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against omicron among mothers and neonates.

SUBMITTER: Rottenstreich A

PROVIDER: S-EPMC9213860 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination.

Rottenstreich Amihai A Vorontsov Olesya O Alfi Or O Zarbiv Gila G Oiknine-Djian Esther E Zigron Roy R Kleinstern Geffen G Mandelboim Michal M Porat Shay S Wolf Dana G DG

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20221101 11

We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates. ...[more]

PMID: 35607735

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