Construction of Immune-Related ceRNA Network in Dilated Cardiomyopathy: Based on Sex Differences.

ABSTRACT: Background: Immune targeted therapy has become an attractive therapeutic approach for patients with dilated cardiomyopathy (DCM) recently. Genetic predisposition and gender play a critical role in immune-related responses of DCM. This study aimed to perform a bioinformatics analysis of molecular differences between male and female samples and identify immune-related ceRNA network in DCM. Methods: The gene expression microarray and clinical features dataset of GSE19303 was downloaded from the GEO. The raw data were preprocessed, followed by identification of differentially expressed genes (DEGs) between male and female DCM samples. Crucial functions and pathway enrichment analysis of DEGs were investigated through GO analysis and KEGG pathway analysis, respectively. A lncRNA-m

SUBMITTER: Liu C 

PROVIDER: S-EPMC9214033 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature