Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC9214044 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Xu Jiajia J Du Wei W Zhao Yunhe Y Lim Kahleong K Lu Li L Zhang Chengwu C Li Lin L
Acta pharmaceutica Sinica. B 20220310 6
Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) are a heterogeneous group of disorders characterized by progressive degeneration of neurons. NDDs threaten the lives of millions of people worldwide and regretfully remain incurable. It is well accepted that dysfunction of mitochondria underlies the pathogenesis of NDDs. Dysfunction of mitochondria results in energy depletion, oxidative stress, calcium overloading, caspases activation, which dominates ...[more]