The differentiation of mesenchymal bone marrow stem cells into nerve cells induced by Chromolaena odorata extracts.

ABSTRACT: Background: Mesenchymal stem cells (MSCs) can differentiate into nerve cells with an induction from chemical compounds in medium culture. Chromolaena odorata contains active compounds, such as alkaloids and flavonoids, that can initiate the transformation of MSCs into nerve cells. The aim of this study was to determine the potential of methanol extracted C. odorata leaf to induce the differentiation of bone marrow MSCs into nerve cells. Methods: A serial concentration of C. odorata leaf extract (0.7-1.0 mg/mL) with two replications was used. The parameters measured were the number of differentiated MSCs into nerve cells (statistically analyzed using ANOVA) and cell confirmation using reverse transcription polymerase chain reaction (RT-PCR). Results:

SUBMITTER: Eriani K 

PROVIDER: S-EPMC9214272 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature