7-O-Galloyltricetifavan: a promising natural radical scavenger.

ABSTRACT: 7-O-Galloyltricetifavan (7OGT), a natural flavonoid, is isolated from the leaves of Pithecellobium clypearia. The compound exhibits a variety of biological activities. This study details the evaluation of the HOO^• antiradical activity of 7OGT by quantum chemistry calculations. The HOO^• trapping activity of 7OGT in the gas phase (reference state) was discovered to follow the formal hydrogen transfer mechanism with a rate constant of k = 4.58 × 10⁸ M^-1 s^-1. In physiological environments, 7OGT is predicted to be an excellent HOO^• radical scavenger with k _overall = 2.65 × 10⁸ and 1.40 × 10⁴ M^-1 s^-1 in water and pentyl ethanoat

SUBMITTER: Hieu LT 

PROVIDER: S-EPMC9214293 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature