Co-component signal transduction systems: Fast-evolving virulence regulation cassettes discovered in enteric bacteria.

ABSTRACT: Bacterial signal transduction systems sense changes in the environment and transmit these signals to control cellular responses. The simplest one-component signal transduction systems include an input sensor domain and an output response domain encoded in a single protein chain. Alternatively, two-component signal transduction systems transmit signals by phosphorelay between input and output domains from separate proteins. The membrane-tethered periplasmic bile acid sensor that activates the Vibrio parahaemolyticus type III secretion system adopts an obligate heterodimer of two proteins encoded by partially overlapping VtrA and VtrC genes. This co-component signal transduction system binds bile acid using a lipocalin-like domain in VtrC and transmits the signal through the membrane to a cy

SUBMITTER: Kinch LN 

PROVIDER: S-EPMC9214523 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature