Medication-Wide Association Study Using Electronic Health Record Data of Prescription Medication Exposure and Multifetal Pregnancies: Retrospective Study.

ABSTRACT:

Background

Medication-wide association studies (MWAS) have been applied to assess the risk of individual prescription use and a wide range of health outcomes, including cancer, acute myocardial infarction, acute liver failure, acute renal failure, and upper gastrointestinal ulcers. Current literature on the use of preconception and periconception medication and its association with the risk of multiple gestation pregnancies (eg, monozygotic and dizygotic) is largely based on assisted reproductive technology (ART) cohorts. However, among non-ART pregnancies, it is unknown whether other medications increase the risk of multifetal pregnancies.

Objective

This study aimed to investigate the risk of multiple gestational births (eg, twins and triplets) following preconception and p

SUBMITTER: Davidson L 

PROVIDER: S-EPMC9214620 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature