Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model.

ABSTRACT: The use of bacteria as an alternative cancer therapy has been reinvestigated in recent years. SL7207: an auxotrophic Salmonella enterica serovar Typhimurium aroA mutant with immune-stimulatory potential has proven a promising strain for this purpose. Here, we show that systemic administration of SL7207 induces melanoma tumor growth arrest in vivo, with greater survival of the SL7207-treated group compared to control PBS-treated mice. Administration of SL7207 is accompanied by a change in the immune phenotype of the tumor-infiltrating cells toward pro-inflammatory, with expression of the T_H 1 cytokines IFN-γ, TNF-α, and IL-12 significantly increased. Interestingly, Ly6C⁺ MHCII⁺ monocytes were recruited to the tumors following SL7207 treatment and were pro-in

SUBMITTER: Johnson SA 

PROVIDER: S-EPMC9214623 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature