Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial.

ABSTRACT:

Importance

The efficacy of multispecies probiotic formulations in the prevention of antibiotic-associated diarrhea (AAD) remains unclear.

Objective

To assess the effect of a multispecies probiotic on the risk of AAD in children.

Design, setting, and participants

This randomized, quadruple-blind, placebo-controlled trial was conducted from February 2018 to May 2021 in a multicenter, mixed setting (inpatients and outpatients). Patients were followed up throughout the intervention period. Eligibility criteria included age 3 months to 18 years, recruitment within 24 hours following initiation of broad-spectrum systemic antibiotics, and signed informed consent. In total, 646 eligible patients were approached and 350 patients took part in the trial.

Interventions

A m

SUBMITTER: Lukasik J 

PROVIDER: S-EPMC9214631 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature