The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19.

ABSTRACT: Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to the cohort study for digital health research in Germany (DigiHero) to respond to a basic questionnaire followed by a PASC-focused survey and blood sampling. We report the first 318 participants, the majority thereof after mild infections. Of those, 67.8% report PASC, predominantly consisting of fatigue, dyspnea, and concentration deficit, which persists in 60% over the mean 8-month follow-up period and resolves independently of post-infection vaccination. PASC is not associated with autoantibodies, but with elevated IL-1β, IL-6, and TNF plasma levels, which we confirm in a validation cohort with 333 additional particip

SUBMITTER: Schultheiß C 

PROVIDER: S-EPMC9214726 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature