Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure.

ABSTRACT:

Aims 

Takotsubo syndrome (TTS) is an acute heart failure, typically triggered by high adrenaline during physical or emotional stress. It is distinguished from myocardial infarction (MI) by a characteristic pattern of ventricular basal hypercontractility with hypokinesis of apical segments, and in the absence of culprit coronary occlusion. We aimed to understand whether recently discovered circulating biomarkers miR-16 and miR-26a, which differentiate TTS from MI at presentation, were mechanistically involved in the pathophysiology of TTS.

Methods and results 

miR-16 and miR-26a were co-overexpressed in rats with AAV and TTS induced with an adrenaline bolus. Untreated isolated rat cardiomyocytes were transfected with pre-/anti-miRs and functionally assessed. Ventricular basal

SUBMITTER: Couch LS 

PROVIDER: S-EPMC9214785 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature