Repurposing of intestinal defensins as multi-target, dual-function amyloid inhibitors via cross-seeding.

ABSTRACT: Amyloid formation and microbial infection are the two common pathological causes of neurogenerative diseases, including Alzheimer's disease (AD), type II diabetes (T2D), and medullary thyroid carcinoma (MTC). While significant efforts have been made to develop different prevention strategies and preclinical hits for these diseases, conventional design strategies of amyloid inhibitors are mostly limited to either a single prevention mechanism (amyloid cascade vs. microbial infection) or a single amyloid protein (Aβ, hIAPP, or hCT), which has prevented the launch of any successful drug on the market. Here, we propose and demonstrate a new "anti-amyloid and anti-bacteria" strategy to repurpose two intestinal defensins, human α-defensin 6 (HD-6) and human β-defensin 1 (HBD-1), as multip

SUBMITTER: Tang Y 

PROVIDER: S-EPMC9214849 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature