Point mutations in SARS-CoV-2 variants induce long-range dynamical perturbations in neutralizing antibodies.

ABSTRACT: Monoclonal antibodies are emerging as a viable treatment for the coronavirus disease 19 (COVID-19). However, newly evolved variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can reduce the efficacy of currently available antibodies and can diminish vaccine-induced immunity. Here, we demonstrate that the microscopic dynamics of neutralizing monoclonal antibodies can be profoundly modified by the mutations present in the spike proteins of the SARS-COV-2 variants currently circulating in the world population. The dynamical perturbations within the antibody structure, which alter the thermodynamics of antigen recognition, are diverse and can depend both on the nature of the antibody and on the spatial location of the spike mutation. The correlation between the motion

SUBMITTER: Ray D 

PROVIDER: S-EPMC9214918 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature