Many kinds of oxidized proteins are present more in the urine of the elderly.

ABSTRACT:

Background

Many studies have shown an association between aging and oxidation. To our knowledge, there have been no studies exploring aging-related urine proteome modifications. The purpose of this study was to explore differences in global chemical modifications of urinary protein at different ages.

Methods

Discovery (n=38) cohort MS data including children, young and old groups were downloaded from three published studies, and this data was analyzed using open-pFind for identifying modifications. Verification cohort human samples (n=28) including young, middle-aged, and old groups, rat samples (n=7) at three-time points after birth, adulthood, and old age were collected and processed in the laboratory simultaneously based on label-free quantification combined with pFind.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9214981 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature