Overexpressed VDAC1 in breast cancer as a novel prognostic biomarker and correlates with immune infiltrates.

ABSTRACT:

Background

More and more evidence suggests that cancer is a mitochondrial metabolic disease recently and mitochondria dysfunction is critical to tumorigenesis. As a gatekeeper of mitochondria, the voltage-dependent anion channel 1 (VDAC1) is associated with the development of breast cancer (BC). However, its potential mechanism and clinical significance remain unclear; thus, in this research, we aimed to explore it.

Methods

VDAC1 expression in BC tissues and normal tissues was obtained from The Cancer Genome Atlas (TCGA) and validated by datasets from the gene expression omnibus (GEO) database. Then, the relationships between VDAC1 expression and clinicopathological features were analyzed. Receiver operating characteristics (ROC) curves were used to identify the diagnostic v

SUBMITTER: Fang Y 

PROVIDER: S-EPMC9215028 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature