Advanced lung cancer inflammation index (ALI) predicts prognosis of patients with gastric cancer after surgical resection.

ABSTRACT:

Introduction

Advanced lung cancer inflammation index (ALI) has been implicated in the prognosis of many types of tumors. But few studies elucidate its role in gastric cancer (GC).

Materials and methods

We consecutively recruited 615 GC patients who underwent radical gastrectomy. Patients were grouped according to ALI status. Risk factors for overall survival (OS) and disease-free survival (DFS) in overall and sex-stratified cohorts were determined using multivariate cox regression analysis. We also compared survival differences between the two groups after one-to-one propensity score matching (PSM).

Results

Patients with low ALI showed larger tumor size, more advanced TNM staging, shorter OS (median: 37 vs 42 months) and DFS (median: 37 vs 42 months) (all P < 0.001).

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9215041 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature