Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA.

ABSTRACT:

Background and purpose

A major challenge in spinal dural arteriovenous fistula (SDAVF) is timely diagnosis, but no specific predictive biomarkers are known.

Methods

In the discovery cohort (case, n = 8 vs. control, n = 8), we used cerebrospinal fluid (CSF) and paired plasma samples to identify differentially expressed proteins by label-free quantitative proteomics. Further bioinformatics enrichment analyses were performed to screen target proteins. Finally, it was validated by ELISA in two of the new cohorts (case, n = 17 vs. control, n = 9), and univariate analysis, simple linear regression, and receiver operator characteristic (ROC) curve analysis were performed to evaluate the diagnostic potential.

Results

In the discovery cohort, the most overexpressed proteins we

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9215050 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature